英國(guó)愛(ài)丁堡大學(xué)Will Wood小組發(fā)現(xiàn)，鐵死亡樣細(xì)胞死亡促進(jìn)并延長(zhǎng)果蠅的炎癥反應(yīng)。相關(guān)論文于2024年6月25日在線發(fā)表于國(guó)際學(xué)術(shù)期刊《自然—細(xì)胞生物學(xué)》。
研究人人員利用活體成像技術(shù)發(fā)現(xiàn)了果蠅胚胎受傷時(shí)體內(nèi)發(fā)生的一種獨(dú)特的、類似于鐵死亡的壞死性細(xì)胞死亡。研究人員進(jìn)一步證明，巨噬細(xì)胞在胚胎內(nèi)迅速與這些壞死細(xì)胞接觸，但卻難以將其吞噬，導(dǎo)致吞噬過(guò)程延長(zhǎng)、受挫和死亡細(xì)胞頻繁解體。相反，在創(chuàng)傷過(guò)程中抑制鐵死亡程序會(huì)延遲巨噬細(xì)胞被招募到損傷部位，這表明鐵死亡在體內(nèi)炎癥過(guò)程中扮演著相互沖突的角色。
據(jù)介紹，鐵死亡是一種獨(dú)特的細(xì)胞壞死形式，由大量脂質(zhì)過(guò)氧化引起，新出現(xiàn)的證據(jù)表明，鐵死亡在多種病癥的器官損傷中起著重要作用。然而，由于缺乏特異性探針，鐵死亡尚未在體內(nèi)可視化，這嚴(yán)重限制了對(duì)免疫系統(tǒng)如何與鐵死亡細(xì)胞相互作用以及這一過(guò)程如何導(dǎo)致炎癥的研究。因此，鐵死亡是否具有生理作用仍然是一個(gè)懸而未決的關(guān)鍵問(wèn)題。
附：英文原文
Title: Ferroptosis-like cell death promotes and prolongs inflammation in Drosophila
Author: Davidson, Andrew J., Heron, Rosalind, Das, Jyotirekha, Overholtzer, Michael, Wood, Will
Issue&Volume: 2024-06-25
Abstract: Ferroptosis is a distinct form of necrotic cell death caused by overwhelming lipid peroxidation, and emerging evidence indicates a major contribution to organ damage in multiple pathologies. However, ferroptosis has not yet been visualized in vivo due to a lack of specific probes, which has severely limited the study of how the immune system interacts with ferroptotic cells and how this process contributes to inflammation. Consequently, whether ferroptosis has a physiological role has remained a key outstanding question. Here we identify a distinct, ferroptotic-like, necrotic cell death occurring in vivo during wounding of the Drosophila embryo using live imaging. We further demonstrate that macrophages rapidly engage these necrotic cells within the embryo but struggle to engulf them, leading to prolonged, frustrated phagocytosis and frequent corpse disintegration. Conversely, suppression of the ferroptotic programme during wounding delays macrophage recruitment to the injury site, pointing to conflicting roles for ferroptosis during inflammation in vivo.
DOI: 10.1038/s41556-024-01450-7
Source: https://www.nature.com/articles/s41556-024-01450-7
期刊信息
Nature Cell Biology：《自然—細(xì)胞生物學(xué)》，創(chuàng)刊于1999年。隸屬于施普林格·自然出版集團(tuán)，最新IF：28.213
官方網(wǎng)址：https://www.nature.com/ncb
投稿鏈接：https://mts-ncb.nature.com/cgi-bin/main.plex
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